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marijuana and cymbalta

HelloMD

“My new doctor told me that my use of cannabis for pain from fbromyalgia would cancel out the effects of Cymbalta for the condition and recommended that I stop using any cannabis products. I have been using them together for years and had found a pretty decent balance for control of my symptoms. I didn’t go with complaints, just a script refill check-up. Intead of asking me if I used weed he said that he wanted to test some levels of possible problems with a blood test. I was not aware of the drug test specific to cannabis until I got my bill in the mail. I have looked for the “many” studies that he says are out there on the subject and have not found much at all. “

Hi there! I have not encountered any studies stating that CBD would interfere in pain relief provided by Cymbalta. Perhaps your doctor was talking about the fact that CBD and Cymbalta compete for the same enzymes involved in their breakdown—as described in the answer I provided (above yours).

However, that would not reduce the efficacy of Cymbalta. In fact, if very high doses of CBD are taken with Cymbalta, that may even lead to a higher serum concentration of Cymbalta to provide pain relief.

What’s worse, is the fact that your physician disregarded your assessment that the combo of CBD and Cymbalta provided superior analgesia when compared to Cymbalta alone. and, without any noticed adverse effects, I imagine.

Also, I’m not sure what blood test he used to measure for CBD, as I am unaware of any such test widely available. She could test for THC. However, that won’t say anything about CBD levels. And what’s the point anyways? “Your blood test is positive for CBD. So, now I know you actually do use CBD.” Perhaps he was checking liver function? If so, tell him studies show CBD as beneficial to liver health.

I hope this helps!

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"My new doctor told me that my use of cannabis for pain from fbromyalgia would cancel out the effects of Cymbalta for…

Drug Interactions between cannabis and Cymbalta

This report displays the potential drug interactions for the following 2 drugs:

  • cannabis
  • Cymbalta (duloxetine)

Interactions between your drugs

cannabis (Schedule I substance) DULoxetine

Applies to: cannabis and Cymbalta (duloxetine)

Using cannabis (Schedule I substance) together with DULoxetine may increase side effects such as dizziness, drowsiness, confusion, and difficulty concentrating. Some people, especially the elderly, may also experience impairment in thinking, judgment, and motor coordination. You should avoid or limit the use of alcohol while being treated with these medications. Also avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medications affect you. Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Drug and food interactions

cannabis (Schedule I substance) food

Applies to: cannabis

Alcohol can increase the nervous system side effects of cannabis (Schedule I substance) such as dizziness, drowsiness, and difficulty concentrating. Some people may also experience impairment in thinking and judgment. You should avoid or limit the use of alcohol while being treated with cannabis (Schedule I substance). Do not use more than the recommended dose of cannabis (Schedule I substance), and avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medication affects you. Talk to your doctor or pharmacist if you have any questions or concerns.

DULoxetine food

Applies to: Cymbalta (duloxetine)

DULoxetine may cause liver damage, and taking it with alcohol may increase that risk. You should avoid or limit the use of alcohol while being treated with DULoxetine. Call your doctor immediately if you have fever, chills, joint pain or swelling, excessive tiredness or weakness, unusual bleeding or bruising, skin rash or itching, loss of appetite, nausea, vomiting, dark colored urine, or yellowing of the skin or the whites of your eyes, as these may be symptoms of liver damage. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See Also

  • Cannabis Drug Interactions
  • Cymbalta Drug Interactions
  • Cymbalta General Consumer Information
  • Drug Interactions Checker
Drug Interaction Classification
These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.

Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some mixtures of medications can lead to serious and even fatal consequences.

A Moderate Drug Interaction exists between cannabis and Cymbalta. View detailed information regarding this drug interaction.