Isomerize cbd to thc
CBD can be easily converted into THC by treating extracted oil with sulfuric acid, a step in the oil trade called “isomerization”.
. as read from griever at http://www.overgrow.com
Direct THC isomerization
Sometimes if pot is totally rank and crappy, or you’re dealing with a bunch of roaches, trimmings, or some other inferior source of THC it is desirable to go well beyond what a simple volatile solvent or super critical fluid extraction can do. You want to convert all those free available cannibinoids into THC, and the only way to accomplish this is a direct isomerization of the Tetrahydracannibinoid. Since any THC isomer is approximately 40% more psychoactive than the nearest related cannabinoid, this will make your product a much stronger concentration and chemically much cleaner than the original. Basic isomerization takes place with a quick reflux of your cannabinoids in the presence of any H+ source (acid).
1. Treat your stuff as if it were a volatile solvent or critical fluid extraction.
2. With the remaining resin, dissolve it in a non-polar solvent. Be sure to use one that separates easily from water such as naphia or white gas.
3. Treat this mixture with sulphuric or hydrochloric acid until a pH around 1-2 is reached (approximately one drop of concentrated acid per gram of extract).
4. Place this in a reflux apparatus and cook it for about an hour. In case you’re not familiar this is basically just Pyrex breaker with a large looped tube plugged into the top. This will cause the solution inside to be exposed to elevated pressures as well as temperatures, as well as preserving all of the original contents. Simply simply boiling the mixture in a small strong covered vessel can mimic it.
5. Wash what’s left with water, keep the oil layer.
6. Neutralize your mix (bring it to pH 7.0) with a little Sodium Hydroxide solution (pH 9.0) or baking soda then rewash it with water. Save the oil layer again.
7. Allow your oil to evaporate and you should be left with a sticky amber liquid that contains almost pure THC.
Now supposedly if processed under more stringent conditions the delta-9-THC can be converted to delta-6-THC which because of it’s stereoscopy could be more psychedelic than the delta-9-THC. The pharmacology shows that the compounds are pretty much analogous in their effects, but if you wish to process your product with a little tolulene and sulphuric acid, followed by a longer than ordinary reflux (10 hours), give it a try. Usually when using this method, your starting solvent is anhydrous methyl or ethyl alcohol, and then the tolulene is added after the refluxing to form a third layer in the mixture, which holds the delta-6-THC. I would recommend a super-critical fluid extraction for a starting point, since if you start clean your product can only get much better. Once you’ve obtained nearly pure THC, converting it to an acetate is supposed to produce more psychedelic like effects.
Basic isomerization takes place with a quick reflux of your cannabinoids in the presence of any H+ source (acid).
so it seems that non THC get turned to THC type cannabinoids in the presence of H+( acid), hence no damage to your THC already present in the mixture oil.
Treatment with acid, according to my understanding, does not cause isomerization of THC, but converts the cannabidiol to delta-9-THC.
Isomerize cbd to thc CBD can be easily converted into THC by treating extracted oil with sulfuric acid, a step in the oil trade called “isomerization”. . as read from griever at
The general procedure and apparatus are identical to those already described for the extraction. The isomerization of CBD to THC is accomplished by refluxing with a small quantity of organic or inorganic acid. If alcohol is being used, add about 2 ml of 1 normal HCl (prepared by adding 120 g concentrated HCl slowly to 900 ml water) or 2 ml of 1 normal sulfuric acid (prepared by adding 30 ml concentrated sulfuric acid slowly to 1 liter of water) for each 200 ml solvent (roughly the amount needed for 100 g of marijuana). If benzene or petroleum ether or other relatively nonpolar solvent (most common ones other than alcohols) are being used, 100 mg paratoluenesulfonic acid or 684 mg (0.006 moles) trifluoroacetic acid are used instead of the HCl or sulfuric acid. Roughly four times as much acid can be used if hashish is being isomerized. The object is to have about 1 g of CBD in 100 ml solvent that is 0.005 molar (about 0.05%) in acid content.
Assemble the apparatus described; add the marijuana, hashish or hash oil; the solvent and the acid; seal and reflux (i.e., heat gently) for about one hour. You can expect about 90% of the CBD to isomerize to A1 THC if an organic solvent such as benzene or petroleum ether is used, but only about 60% yield of A1 and A6 THC’s with other products (e.g., ethoxyhexahy-drocannibinols) if ethanol or another alcohol is used. If the can-nabinoids have already been extracted; i.e., if you have hash oil, you may simply dissolve the oil in solvent and heat with acid to get isomerization. For example, a saturated solution of paratoluenesulfonic acid in methylene chloride heated at 80° F for 45 minutes gives about 90% yield of THC. As the reaction times are increased, more A1 THC will isomerize to A6 THC, but since the two have nearly the same activity, this does not matter. For oil, use about 5 ml oil per 100 ml solvent.
The solvent may now be removed, leaving the isomerized cannabinoids behind as an oily residue (deposited on the marijuana if this is left in). Solvent removal is accomplished exactly as described in the extraction section. Although the amount of acid used is small, you may wish to neutralize it with a small quantity of base, such as baking soda, prior to evaporation of solvent. Also, if you have used alcohol for isomerization (or extraction), you may shake the large volumes of alcohol containing the cannabinoids with benzene, petroleum ether, or other nonpolar solvents. The cannabinoids are much more soluble in the latter, and the smaller volume is easier to evaporate. Again, if the latter solvents are used, it is good to wash them with water several times (i.e., shake with an equal volume of water and discard the water) before evaporation to rid them of the undesirable water soluble substances, even if the marijuana has been water-extracted prior to isomerization (David Hoye’s “Double Wash” technique).
The area of extraction and isomerization has been pioneered by David Hoye, inventor of the world’s first automated isomerizer. At S179 this machine may seem over-priced, but it has the advantage of being significantly safer than home-built apparati. One can easily imagine this machine becoming a common item in the American kitchen along with the toaster and electric blender. However, claims that it will double the potency of any marijuana without weight loss are obviously untrue. This would require about twice as much CBD as THC being present, a very rare situation with commercial marijuana.
The general procedure and apparatus are identical to those already described for the extraction. The isomerization of CBD to THC is accomplished by refluxing