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How long does it take CBD to work?

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Contents

  1. How does CBD interact with the body?
  2. The method of consumption matters
  3. Dosage matters
  4. How long does it take CBD to get out of your system?

So, you’ve heard about cannabidiol (CBD) oil possibly working wonders for chronic pain relief, anxiety, and many other conditions. You finally sit down, unscrew the cap from the CBD oil bottle, and prepare to set out on a soothing journey guided by this non-intoxicating cannabinoid. After taking a few drops of CBD oil or applying a CBD-infused topical to the skin, you might start to ponder the following questions:

  • How long does it take for CBD to work?
  • How long will the effects of CBD oil last?

More clinical research is required to answer these questions with unwavering confidence, but we can still look at how CBD interacts with the body to come up with well-educated estimates.

How does CBD interact with the body?

CBD interacts with the brain and body through a number of different mechanisms, creating a complex relationship that still merits further research before we can fully understand how this cannabinoid might relieve certain ailments.

Upon entering the system CBD interacts with a wide range of proteins in the body and central nervous system. A key part of this interaction takes place within the endocannabinoid system (ECS), specifically the CB1 and CB2 cannabinoid receptors. Unlike THC, which is the intoxicating cannabinoid that binds to these receptors and creates the stoned effect, CBD actually has an inverse effect. When cannabidiol is introduced to the ECS, it inhibits the absorption of anandamide, a natural cannabinoid that regulates pain.

When cannabidiol is introduced to the endocannabinoid system, it inhibits the absorption of anandamide, a natural cannabinoid molecule that regulates pain. Photo by: Gina Coleman/Weedmaps

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CBD also interacts with other receptor proteins not directly related to the ECS, such as the serotonin receptor 5-HT1A and vanilloid receptor TRPV1. The widely perceived anti-inflammatory and pain relieving properties of CBD could stem from the activation of these additional biological pathways.

The relationship between CBD and the human body is rather complicated, but it’s a bit easier to understand how this cannabinoid moves through the body, as well as how long it takes CBD to leave your system. Even this answer, however, is contingent on several factors, including the method of consumption, the quality of the CBD product, and the person consuming CBD.

The method of consumption matters

Method of consumption plays a critical role in how long it will take to feel the effects of CBD. CBD is available in many different forms, and each has an influence on the onset time, among other factors.

Ingestion

The most common method for CBD consumption involves administering a couple of drops directly into the mouth. It is the quickest and easiest way to reap the potential benefits of this cannabinoid. But quickly swallowing the oil also prevents CBD from immediately entering the bloodstream, sending it instead through the digestive tract and eventually on to the liver, where it is broken down before finally reaching the bloodstream.

Studies show that when CBD compounds are metabolized by the liver, it undergoes what is called the “first pass effect,” where enzymes in the liver reduce CBD concentration before the remainder is finally sent to the bloodstream to be circulated throughout the body.

Administering a couple of drops of CBD oil directly into the mouth is the quickest and easiest way to reap the benefits Photo by: Gina Coleman/Weedmaps

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For ingestion of CBD edibles, the same principle applies. Let’s say, for example, you’re taking CBD gummies or adding a few drops of CBD oil into your favorite recipe. It will ultimately go through the same lengthy process and reduce the total CBD concentration found in your blood stream. With ingestion, it could be one to two hours before the effects of CBD finally set in.

Sublingual

CBD oil can be consumed sublingually by placing a few drops of CBD under the tongue before swallowing. By using this method, CBD is absorbed by the mucous membranes located in the mouth, bypassing the digestive system and liver. Compared with ingestion, this process allows the consumer to skip over the initial metabolization process, where CBD molecules are broken down in the liver, allowing it to enter the bloodstream more quickly.

Inhalation

Whether you’re smoking a high-CBD strain or taking a draw from a CBD vape pen, inhalation is often seen as an effective method of delivery for CBD because of how quickly it’s absorbed in the body. When CBD is smoked or vaped, cannabinoids are sent directly to the lungs, where they are rapidly absorbed into the bloodstream and put into circulation throughout the body. It reaches peak concentrations within three minutes after consumption, meaning the effects can be felt shortly after use.

Topical

Topical CBD is applied directly to the skin and can be absorbed through the surface of the skin to interact with localized cannabinoid receptors. In some cases, CBD-infused topicals should be applied liberally to overcome the low cannabinoid absorption rate of the skin. When CBD is applied topically, the effect peaks at about 90 minutes. This method of administration is often used for chronic pain in specific areas.

Topical CBD is applied directly to and can be absorbed through the surface of the skin. Photo by: Gina Coleman/Weedmaps

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Dosage matters

The way CBD operates throughout the body – and is inevitably excreted from the body – also depends on several factors that vary from person to person.

Body weight

The amount of body fat influences the amount of CBD needed to be effective. Someone with a larger body mass will require more CBD in order to feel the effects. Body weight and mass also affect how long CBD remains in the system. Like THC, CBD is stored in fat cells and gradually eliminated from the body through urine and feces. Does CBD have to build up in your system to work effectively? No, but it does get stored in the fat cells and can remain in the body well after the effects of CBD diminish.

Metabolism

The metabolic rate of the individual also has some sway over how long CBD stays in the system. The body’s metabolism determines how long it takes to break down and synthesize compounds, which affects how long it takes the body to process and metabolize the cannabinoid.

The body’s metabolism affects how long it takes to process and metabolize cannabinoids. Photo by: Gina Coleman/Weedmaps

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Frequency of use

It’s not just the human body that influences how long it takes CBD to work, but also the quality of the CBD product and how often it’s used. Once the CBD oil is acquired, the next step is to find the optimal dosing regimen, including frequency of use. Perhaps you’ve wondered to yourself:

  • Should I take CBD oil in the morning or at night?
  • What’s the right time of day to take CBD?

The answers will depend largely on the type of product, amount of CBD inside it, and the specific ailment you are targeting. Most reputable manufacturers will provide instructions on how to properly utilize the product, but experimentation may be required to find the optimal dose for you and your specific needs.

CBD dosage

Settling on the ideal CBD dosage is an important part of the treatment process, and will also impact how long CBD stays in your system.

Hemp-derived CBD products are not intended to give the user a stoned buzz or intoxicated feeling, so there’s no need to be conservative with the dosage amount. Still, it’s recommended to start with a lower dosage and gradually increase it until the ideal effects are discovered.

How long does it take CBD to get out of your system?

We’ve covered the factors that determine how long it takes for CBD to work, but what about how long it takes to get CBD out of your system? Again, it depends on many of the aforementioned factors that determine the effectiveness of the cannabinoid itself.

A 2007 study states that CBD can be detected up to 72 hours after smoking. Since the effects of CBD may be felt directly after inhalation, this method is appealing for those seeking immediate pain relief. In another study, volunteers were given soft-gelatin capsules of cannabis extract containing 2.5 milligrams of THC and 1.35 milligrams of CBD. The research team found that CBD was only detectable in the blood for up to six hours after ingestion.

CBD can be detected up to 72 hours after smoking. Photo by: Gina Coleman/Weedmaps

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Some people may be apprehensive to try CBD over concerns that it could cause them to fail a drug test. It’s highly unlikely that CBD would show up on most drug screenings, as most tests specifically look for the presence of THC and THC metabolites. But even hemp-derived CBD can contain trace amounts of THC, so there’s technically a chance, albeit extremely slim, of receiving a false positive test result from taking an unusually large dose (estimates range from 1,000 to 2,000 milligrams per day) of CBD oil.

For those worried about THC showing up in their system, look for broad-spectrum oil or products that contain pure CBD isolate. Broad-spectrum oil, as opposed to full spectrum oil, is refined to exclude the trace amounts of THC that may have been present in the hemp plant. Products with CBD isolate contain no THC or other plant-based cannabinoids. To find high-quality CBD, search for products that come with a certificate of analysis from a third-party testing lab to ensure that the information listed on the product label is accurate. Also, be on the lookout for products that claim to be hemp seed oil or hemp oil, which seldom contains any CBD at all.

How long does it take CBD to work? Copy article link to clipboard. Link copied to clipboard. Contents How does CBD interact with the body? The method of consumption matters

How Long Does CBD Last?

How Long Does CBD Last?

Depending on how you take your CBD, the effects could last as long as two days!

With CBD oil becoming more widely available, it is being sought out by an ever-growing number of people due to its potential health benefits. The list of CBD’s reported therapeutic uses is also ever-growing, leading many people to consider trying it for the first time.

This increased interest in CBD oil tends to raise many questions, with one of the most common being, “how long does CBD last?” If you’ve never taken cannabidiol (CBD) before, knowing how long its effects will linger is important for nailing down your ideal dosage, and ultimately deciding if CBD oil is right for you.

Here’s your guide to how long CBD lasts, as well as information on what factors can affect its duration and onset.

CBD Delivery Methods and Duration of Effects

Depending on the product you use and your individual biochemistry, CBD oil can last anywhere from 30 minutes to 2 days.

For example, edible preparations of CBD oil, like gummies, can last between 4-6 hours while a CBD oil transdermal patch can last up to 48 hours. A CBD vape oil’s effects can disappear within an hour while a CBD oil tincture can last 2-4 hours.

When choosing a CBD oil delivery format, these durations need to be taken into account. If you are trying to relieve an ongoing chronic pain condition, it is likely that you will want a format that offers longer relief versus one that presents shorter-lived (but often faster-acting) effects.

CBD Duration Chart

CBD edibles, capsules, tinctures, vaporizers, flower and topical creams are all methods for taking CBD, and each has its own time for onset and duration of effects.

CBD Oil Delivery Format Onset of Effects Duration of Effects
CBD inhalants (Vape oils; vape juice; e-liquid; CBD flower) Within minutes – These products bypass the digestive process and are absorbed directly into the lungs 30 minutes to an hour
CBD Edibles Up to 60 minutes – Edibles must pass through the digestive system before being absorbed through the liver 4-6 hours
CBD Oil Tinctures or Drops Up to 30 minutes – Drops and tinctures bypass the digestive system and CBD is absorbed directly into the bloodstream through the thin skin under the tongue 2-4 hours
CBD Oil Capsules Up to 60 minutes – CBD capsules must pass through the digestive system before being absorbed 4-6 hours
CBD Oil Topicals Up to 2 hours – Topicals must be absorbed through the skin. The CBD’s absorption rate can be impacted by the amount of hair on the skin and fatty tissue under it Typically 5 hours or more
CBD Oil Transdermal Patches May take hours to show effects – The CBD’s absorption rate can be impacted by the amount of hair on the skin and fatty tissue under it; Transdermal patches may also be designed to release CBD at certain time intervals over the course of their relatively long lifetime 24-48 hours

There really is no universal answer to how long CBD will last in your body. With many factors playing a part in CBD’s duration and the onset of effects, it can impact each person a little differently. By keeping the initial dosages low, you can see how you react before fully adopting a regular CBD oil routine.

Factors that Affect How Long CBD Lasts

How you choose to take CBD oil is not the only factor that determines the duration of its effects.

Other factors that affect how long CBD lasts in the body include body weight, certain lifestyle choices, how frequently you use it, and dosage.

Your Body Weight

Cannabidiol (CBD) is a fat-soluble compound. What this means is that it is stored in the body’s fat cells. With any fat-soluble substance, like vitamin D or vitamin K, weight plays a role in CBD oil’s rate of metabolization.

If you’re on the leaner side with a lower body fat percentage, CBD’s effects may not last as long as in a person with a higher body fat percentage. Typically, people with more muscle than fat have a higher metabolic rate which means substances like CBD oil will be processed through the body much faster, reducing the duration of their effects.

Your Lifestyle

Another factor that plays a role in how long CBD lasts in the body is lifestyle and activity level. If you lead an active lifestyle, your body is likely to process CBD more quickly because your metabolism will be faster, resulting in a reduced duration of effect.

Your Frequency of Use

The frequency with which you use CBD oil can influence its effects. Unlike other substances, it is unlikely that you will build a tolerance to CBD. In fact, it’s theorized that CBD creates a “reverse tolerance.” Simply put, with repeated use of CBD oil, it is likely that you will require less to feel the desired effects over time. It is believed that CBD increases the presence of naturally produced endocannabinoids in the body, so as your body adapts to create equilibrium, you require less to get the same effects.

If you take CBD regularly, the reverse tolerance you build could cause you to feel its effects for a shorter perceived amount of time.

Your Dosage

The more CBD oil you take, the longer it will take for your body to process it, and the longer the effects will last.

However, it is recommended that you begin with the lowest recommended dose on your CBD oil product. Until you know how CBD oil will impact you, it is best to take it slow.

To make dosing CBD as easy and as straight-forward as possible, CBD Oil Review has researched and tested many of the top CBD products on the market today, to come up with a standard serving suggestion for you to follow:

The CBD Oil Review Serving Standard is 25mg of CBD, taken twice daily.

It is recommended that you be patient and stick with this dose for a few weeks before considering an increase in dosage. If after 3 to 4 weeks, you’re not getting the results you were after, consider upping your dose by 25mg. Continue increasing your dose in this way, until you get the desired results.

For detailed information on CBD dosing, check out our dosing guide.

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