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We recruited the sepsis population from the Beth Israel Deaconess Medical Center Emergency Department. Study inclusion criteria for the sepsis population were: 1) adult patients (age 18 years or older) who exhibited sepsis, as defined by the presence of an infection (determined by the clinical treating team) and the presence of at least two SIRS criteria using a modified definition of the American College of Chest Physicians/Society of Critical Care Medicine.(Bone, 1992, Singer et al., 2016) The SIRS criteria include: temperature > 100.4 °F or 90 beats/min, respiratory rate > 20 breaths/min or partial pressure of carbon dioxide 12.000/μl or 10% bands. An additional non-infected control population was similarly recruited from the emergency department where patients had to meet the following criteria: 1) adult (> 18 years old) 2) absence of infection, and 3) absence of meeting two or more SIRS criteria. We also recruited trauma patients who were adult emergency department patients with a traumatic injury (long bone fracture or hollow viscous injury) without documented infection.

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