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In order to give you the best experience, we use cookies and similar technologies for performance, analytics, personalization, advertising, and to help our site function. You can change your preferences any time in your Privacy Settings. Each bottle contains a 120-day supply of 3-milligram melatonin tablets. Note that short-term usage of melatonin supplements may be safe for most people, however, data on long-term usage is lacking.   Nature Made recommends taking 1 tablet with water 1 hour before bedtime. CBD oil has the potential to disrupt an enzyme known as the cytochrome P450 complex. The destruction of cytochrome P450 complex can hinder the liver’s ability to break down toxins, thereby increasing the chances of liver toxicity.

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