Categories
BLOG

cbd central augusta ga

Cannabidiol (CBD) modulation of apelin in acute respiratory distress syndrome

Affiliations

  • 1 Department of Oral Biology and Diagnostic Sciences, Dental College of Georgia, University, Augusta, GA, USA.
  • 2 Center for Excellence in Research, Scholarship and Innovation, Dental College of Georgia, Augusta University, Augusta, Augusta, GA, USA.
  • 3 Department of Neurosurgery, Medical College of Georgia, Augusta University, Augusta, GA, USA.
  • 4 Department of Pathology, Medical College of Georgia, Augusta University, Augusta, GA, USA.
  • 5 Department for Cell and Developmental Biology, Institute of Biomedical Sciences -Federal, University of Alfenas, Alfenas, Brazil.
  • 6 European Medical Association (EMA), Brussels, Belgium.
  • 7 Children’s Hospital of Georgia and Medical College of Georgia, Augusta University, Augusta, GA, USA.
  • 8 Department of Neurology, Medical College of Georgia, Augusta University, Augusta, GA, USA.
  • PMID: 33058425
  • DOI: 10.1111/jcmm.15883

Free article

Cannabidiol (CBD) modulation of apelin in acute respiratory distress syndrome

  • Search in PubMed
  • Search in NLM Catalog
  • Add to Search

Authors

Affiliations

  • 1 Department of Oral Biology and Diagnostic Sciences, Dental College of Georgia, University, Augusta, GA, USA.
  • 2 Center for Excellence in Research, Scholarship and Innovation, Dental College of Georgia, Augusta University, Augusta, Augusta, GA, USA.
  • 3 Department of Neurosurgery, Medical College of Georgia, Augusta University, Augusta, GA, USA.
  • 4 Department of Pathology, Medical College of Georgia, Augusta University, Augusta, GA, USA.
  • 5 Department for Cell and Developmental Biology, Institute of Biomedical Sciences -Federal, University of Alfenas, Alfenas, Brazil.
  • 6 European Medical Association (EMA), Brussels, Belgium.
  • 7 Children’s Hospital of Georgia and Medical College of Georgia, Augusta University, Augusta, GA, USA.
  • 8 Department of Neurology, Medical College of Georgia, Augusta University, Augusta, GA, USA.
  • PMID: 33058425
  • DOI: 10.1111/jcmm.15883

Abstract

Considering lack of target-specific antiviral treatment and vaccination for COVID-19, it is absolutely exigent to have an effective therapeutic modality to reduce hospitalization and mortality rate as well as to improve COVID-19-infected patient outcomes. In a follow-up study to our recent findings indicating the potential of Cannabidiol (CBD) in the treatment of acute respiratory distress syndrome (ARDS), here we show for the first time that CBD may ameliorate the symptoms of ARDS through up-regulation of apelin, a peptide with significant role in the central and peripheral regulation of immunity, CNS, metabolic and cardiovascular system. By administering intranasal Poly (I:C), a synthetic viral dsRNA, while we were able to mimic the symptoms of ARDS in a murine model, interestingly, there was a significant decrease in the expression of apelin in both blood and lung tissues. CBD treatment was able to reverse the symptoms of ARDS towards a normal level. Importantly, CBD treatment increased the apelin expression significantly, suggesting a potential crosstalk between apelinergic system and CBD may be the therapeutic target in the treatment of inflammatory diseases such as COVID-19 and many other pathologic conditions.

Keywords: ARDS; CBD; COVID-19; apelin; cannabidiol; inflammation.

© 2020 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd.

Considering lack of target-specific antiviral treatment and vaccination for COVID-19, it is absolutely exigent to have an effective therapeutic modality to reduce hospitalization and mortality rate as well as to improve COVID-19-infected patient outcomes. In a follow-up study to our recent findings …

404: Page Not Found

This page could not be found!

We are sorry. But the page you are looking for is not available.
Perhaps you can try a new search.

Lab Info
  • The Higgins Lab at Columbia University
About the Lab
  • Research Areas
  • Current Projects
  • People
  • Publications
  • Join The Lab

© 2019 Higgins Lab

Electronic versions of our publications are provided as a courtesy to facilitate timely dissemination of academic work for individual, noncommercial purposes. All rights reside with the respective copyright holders.

404: Page Not Found This page could not be found! We are sorry. But the page you are looking for is not available. Perhaps you can try a new search. Lab Info The Higgins Lab at