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Mushrooms and Cannabis: A Primer on Mixing Psilocybin with THC and CBD

by Roderick | Dec 20, 2019

With legalization in Canada, cannabis is more available than ever before – mixing mushrooms and cannabis is an inevitability. Anecdotes abound in reference to smoking or eating the substance alongside a mushroom experience. In the spirit of education on this newly legal herb, we took a deeper look at the science surrounding the combination of mushrooms and marijuana.

Cannabis can “intensify the mushroom experience,” but may also “cloud” the psilocybin adventure. The timing of mixing the two also seems to play a role, with different outcomes depending on the progression of the trip. Ultimately, the conclusion seems to be that previous experience with both substances is a substantial advantage to obtaining positive outcomes.

To better understand the interwoven effects of mixing two different substances, it’s best to have a clear picture of what each accomplishes on its own. When it comes to psychoactive chemicals, every person will have their own experience; the expectations and results explained here are only a suggestion.

‘Shrooms’ or Magic Mushrooms

Active Compounds

Shrooms, the most common being Psilocybe cubensis, contain low but consistent levels of psilocybin and psilocin, the primary active compounds of “magic mushrooms.” There are a few other chemicals found in mushrooms – suspected to contribute to the subjective experience – but the evidence is lacking.

The Mushroom Experience

Considered an “upper” (similar to a sympathetic arousal state) though may also produce a “body high”. Characterized by euphoria, visual and mental hallucinations, changes in perception, a distorted sense of time, spiritual experiences, giddiness, joy, open and closed eye visuals (common at medium to high doses), along with synesthesia (e.g. hearing colours and seeing sounds). The mind-altering effects of psilocybin typically last from two to six hours.

The Side Effects of Psilocybin

Possible adverse reactions such as nausea and panic attacks, about a third of users report feelings of anxiety or paranoia. Feelings of disorientation, lethargy, and depression. Tachycardia, dilated pupils, restlessness or arousal, increased body temperature, headache, sweating and chills.

Known Interactions

Aside from direct MAOIs, tobacco smokers may experience more powerful effects with psilocybin, because tobacco smoke exposure decreases the activity of MAO in the brain and peripheral organs.

Psilocybin Pharmacology

Psilocybin is rapidly metabolized to psilocin, which acts directly on serotonin receptors in the brain. It partially activates several serotonin receptors. Psilocin has a high affinity for the 5-HT2B and 5-HT2C receptors in the human brain, and with a slightly lower affinity for the 5-HT2A. Psilocin further binds with low affinity to 5-HT1 receptors, including 5-HT1A and 5-HT1D. In addition, psilocin indirectly increases the concentration of the neurotransmitter dopamine in the basal ganglia. Finally, psilocin is degraded by the enzyme monoamine oxidase in the liver, lungs and gut.

Cannabis or Marijuana

Active Compounds

Cannabis research has quickly discovered hundreds of cannabinoids and terpenes that may be active in some form. The multitude of strains promotes the subtle variance in Tetrahydrocannabinol (THC) and Cannabidiol (CBD), the primary active ingredients in hemp. The perceived differences in the modifications to the ratio between the two, along with a host of other suspected active compounds, allows for some discretion in modifying the mushroom experience with cannabis.

The compound CBD specifically may be helpful in countering the negative effects of mushroom usage; considered to reduce the “jitters,” balancing the effects of THC in reducing disorientation, tachycardia, and eventual drowsiness. This may be due to the data that has shown it to act as a serotonin receptor activator.

These two active compounds are further implicated in reducing nausea induced by many things, whether it be disease or other substances. The multitude of other compounds may provide a plethora of effects as well, depending on the personal metabolism and physiology of the user.

The Cannabis Experience

Generally considered to be a “downer.” Attributed to CBD, especially prevalent in Indica cultivars. Creates a “high” or “stoned” feeling, a general change in perception, heightened mood, and an increase in appetite.

The Side Effects of Cannabis

A decrease in short-term memory, dry mouth, impaired motor skills, red eyes, and feelings of paranoia or anxiety.

Cannabis Pharmacology

THC exerts its most prominent effects via its actions on two types of cannabinoid receptors, the CB1 receptor and the CB2 receptor. Further, THC indirectly increases dopamine release. Cannabidiol (CBD) also acts as an allosteric modulator of the μ- and δ-opioid receptors. Metabolism occurs mainly in the liver by cytochrome P450 enzymes CYP2C9, CYP2C19, and CYP3A4.

Mixing Shrooms and Cannabis

The Experience

In general, mixing cannabis and shrooms intensifies the experience by triggering more abstract or thought-provoking visuals and sensations. This can be especially apparent near the end of a mushroom experience, prolonging the related visuals and changes in perception. THC-rich strains, primarily C. sativa, may assist in providing extra energy and positivity. CBD-rich strains, primarily C. indica, may assist in reducing nausea and limiting anxiety or “jitters.”

The Downsides

The primary downside to mixing cannabis and mushrooms is their combined ability to provoke paranoia and anxiety. Together, they can also increase the risk of negative emotions or repetitive thoughts. Combined with the disorientation of time associated with mushrooms, cannabis can make a poor experience feel even longer. Finally, an overall “disconnect” due to marijuana-induced lethargy may dull visuals and numb sensations.

Known Interactions

Both substances have an indirect effect on the brain chemical dopamine, commonly known as the “feel good” or “reward” drug in the brain. While this can foster motivation and drive during a trip, it can equally be cut by indecision or repetitive thoughts. As mentioned above, THC (found abundantly in Sativa strains) can boost and energize the sensations provided by the mushrooms; CBD (primarily in Indica strains) can calm a fast adventure or ease nausea and anxiety in beginners.

Combining magic mushrooms and marijuana

For those experienced with the medicinal or spiritual use of magic mushrooms, or those who consume cannabis daily, the combination of the two may enhance and ease the exploration of ideas and the mind. Considering the effects of magic mushrooms when compared to cannabis, the herb is often seen as an accompaniment to the fungus. Timing of marijuana consumption along the duration of the trip can provide significant control over the outcomes.

Before

Cannabis at the beginning of an experience can enhance the entirety, ease initial nausea, and remove any “rough transitions” that may arise while “coming up.” It can also help relieve anxiety or impatience associated with the relatively long duration of mushroom onset.

During

Once underway into the mushroom adventure, cannabis may seem unappealing to the average user, but experienced users can consider it to amplify the height of the sensations. Smoking can feel like a daunting undertaking, making the application of cannabis edibles at this point a viable alternative.

After the peak

Past the peak, cannabis seems to enact its most potent synergy with magic mushrooms. Enhancing the already modified perception of time, the combination can greatly enhance the duration of lesser sensations and visuals. It can also help to damper any negative emotions that may accompany the waning hours of a trip. Finally, it can help slow thought and provide deeper context to the contemplation of recent experience.

Ultimately, the combining of any two substances is best left to those who have experience individually with both. For those prone to anxiety or “bad trips,” cannabis is best left until the end or when the mushroom sensations are well under control. This prevents dulling the “come up” that can be so awe-inspiring among initiates, and further prolong the visuals and thoughts the mushrooms provide.

For those seeking to enhance their experience, or explore more nuanced depths and heights, the combination of magic mushrooms and cannabis is a considerable suggestion. Applying cannabis to a fungal voyage can be a tactical way to enhance or inhibit sensations of all kinds.

van Amsterdam J, Opperhuizen A, van den Brink W (2011) “Harm potential of magic mushroom use: a review”. Regulatory Toxicology and Pharmacology 59 (3): 423–9.

Kathmann M, Flau K, Redmer A, Tränkle C, Schlicker E (2006) “Cannabidiol is an allosteric modulator at mu- and delta-opioid receptors”. Naunyn-Schmiedeberg’s Archives of Pharmacology. 372 (5): 354–61.

Cannabis can intensify the mushroom experience, but it may cloud the psilocybin adventure. Learn why and how to mix magic mushrooms and cannabis.

7 Benefits Of Combining CBD and Magic Mushroom

Magic Mushrooms and cannabis are two popular natural supplements that produce a euphoric effect when consumed. Combining them can intensify the pleasant and mind-altering experience these drugs give. The chemical compounds in cannabis can alter the psilocybin in mushrooms to provide positive outcomes. There seem to be substantial positive outcomes in combining these plant herbs.

Let’s first understand what these substances are before we know the benefits of combining Mushroom and CBD.

Magic Mushroom

Magic mushrooms or shrooms are a group of fungi that comprise psychoactive components psilocybin and psilocin. These active agents are the reason behind the mind-altering and euphoric effects in the user. The users of magic mushrooms start feeling its impact within 20 minutes and can last up to a maximum of 3 days.

Cannabidiol(CBD)

Cannabidiol is one of the main constituents in the marijuana plant, apart from tetrahydrocannabinol (THC). THC is the component that causes the euphoric effect in people, whereas CBD is non-intoxicating in nature. This non-psychoactive quality of CBD makes it suitable for various physical and mental health benefits.

Mixing Shrooms and Cannabis

The after-effects of taking cannabis and shrooms combined is an intensified version of intriguing visuals and emotions. Cannabidiol can help treat ailments like pain, anxiety, insomnia, and other disorders, whereas shrooms can also treat similar disorders like anxiety, nausea, and pain in cancer patients. When consumed in moderation, both plant-based products have hardly any adverse-effects, making them a better option than other over-the-counter medications.

Keep reading to know the various enhanced benefits these two ingredients have to offer when combined.

1. Reduces Anxiety

Anxiety and depression have become a part of our daily lifestyle and takes a considerable toll on mental as well as physical health. Overthinking and negative thoughts can lead to chronic anxiety, which eventually starts affecting people’s day-to-day activities.

Magic mushrooms and CBD can act as antidepressants. The psilocybin in mushrooms influences the brain to affect the serotonin levels. It binds with the serotonin receptors to subdue negative thoughts.

On the other hand, CBD exhibits an anxiolytic effect that reduces the stress levels in the user. It also acts on the brain to regulate how the brain chemicals respond to serotonin levels. There are many ways of taking CBD like CBD oil, tinctures, and CBD edibles, of which the most popular one is CBD gummies.

Thus, combining CBD and mushrooms can help enhance positive feelings, control mood swings leading to better mental health by slowing down anxiety triggers.

2. Improves Concentration

Mushrooms and CBD can work together to enhance the concentration and focus level of a person. Anecdotal accounts show that consuming mushrooms can help boost memory, grasp better and faster, leading to improved performance at exams and work. Additionally, magic mushrooms effects can also reconstruct a person’s imagination, feelings, and open-mindedness.

CBD also gives similar results by increasing the production of the body’s natural endocannabinoids providing improved brain functionality. Both CBD and psilocybin help decrease the stress levels, which also contribute to enhanced memory and focus. They also help in developing the intensity of conceptual thinking.

Thus, combining mushrooms and CBD can be beneficial in increasing the concentration levels in people.

3. Improve Gut health

Poor digestive health is a result of inadequate water intake, stress, eating a lot of junk food, and sleeping disorder. The problems with gut health start with a stomach ache, which then leads to headaches and affects various other organs.

Mushrooms contain an abundance of antioxidants and anti-inflammatory qualities that help in healing the gut. As per a journal, mushrooms can start bile creation in the stomach for smooth digestion.

CBD also is anti-inflammatory in nature that can treat digestive issues and Irritable Bowel diseases. Therefore, combining mushrooms and CBD can deliver powerful benefits to gut health, improve appetite, and protect the digestive system from harmful bacteria.

4. Reduces Fatigue

Fatigue happens due to a lack of sleep and improper eating habits. As per an article, the women’s team who took mushrooms daily before their big event showed a hike in their energy levels. It increased their workout levels, strength, and stamina. Daily consumption of fungi can also help in building healthy bone structure.

Mixing CBD with mushrooms can help reduce muscle soreness. A journal suggests that CBD can fight fatigue by inducing muscle relaxation and aids in fast recovery.

Thus, combining magic mushroom and CBD helps a person feel energized and refreshed to take on the next day.

5. Stimulates Growth Of New Brain Cells

Mushrooms and CBD both help in neurogenesis. Individual studies on both substances have proved their potential in the growth of new brain cells. A PubMed article reveals that psilocybin, the active compound in mushrooms, can promote the growth of new neurons and regeneration.

Similarly, CBD interacts with the endocannabinoid receptors to activate the CB1 receptors, stimulating new brain cells.

Both mushrooms and CBD combined will enhance cognitive skills, neuronal plasticity, and heal neurodegenerative disorders.

6. Boosts Immunity

Mushrooms can stimulate cell immunity in humans. As per an article, they possess beta-glucans that are absent in humans. When these beta-glucans come into contact with human cells, they ignite the human body’s immune system. Mushrooms are also a rich source of protein, fiber, and antioxidants, which protect the tissues and cells from any damage.

Another recent study also revealed that mushrooms prevent tumor spread and combat cancer.

Cannabidiol also has a similar impact on the human body due to its strong antioxidative properties. It reduces oxidative stress and gives relief from pain.

A blend of shrooms and CBD can give enhanced immunity, lessen pain, and reduce side-effects of chemotherapy in cancer patients.

7. Combats Addiction

Repeated use of drugs or cravings for a substance leading to significant distress is a sign of drug addiction. The psilocybe cyanescens in magic truffles has a positive influence on curing alcohol dependence. An experiment was conducted on ten patients suffering from alcohol addiction wherein the researchers ingested a dose of psilocybin for four weeks into the patients. After four weeks, the researchers found a significant decrease in alcohol consumption in the patients. Thus, the magic mushroom has anti-addictive effects on people with an addiction problem.

Similarly, a 2015 review shows that CBD acts on the endocannabinoid system to provide relief from the addictive urges. It can prevent relapses in drug and alcohol addicts.

Thus, combining magic mushroom and CBD can provide long-lasting benefits in fighting substance addiction.

Conclusion:

The combination of magic mushroom and CBD has positive effects on a person’s physical and mental health. Consuming it in a defined dosage will let you enjoy their benefits without any side-effects. However, one must always consult a doctor before trying on these drugs to understand the suitable dosages.

7 Benefits Of Combining CBD and Magic Mushroom Magic Mushrooms and cannabis are two popular natural supplements that produce a euphoric effect when consumed. Combining them can intensify the