cbd and ibuprofen

Drug Interactions between cannabis and ibuprofen

This report displays the potential drug interactions for the following 2 drugs:

  • cannabis
  • ibuprofen

Interactions between your drugs

No interactions were found between cannabis and ibuprofen. This does not necessarily mean no interactions exist. Always consult your healthcare provider.


A total of 377 drugs are known to interact with cannabis.

  • Cannabis is in the drug class illicit (street) drugs.
  • Cannabis is used to treat the following conditions:
    • AIDS Related Wasting
    • Muscle Spasm
    • Nausea/Vomiting, Chemotherapy Induced
    • Pain


A total of 357 drugs are known to interact with ibuprofen.

Drug and food interactions

cannabis (Schedule I substance) food

Applies to: cannabis

Alcohol can increase the nervous system side effects of cannabis (Schedule I substance) such as dizziness, drowsiness, and difficulty concentrating. Some people may also experience impairment in thinking and judgment. You should avoid or limit the use of alcohol while being treated with cannabis (Schedule I substance). Do not use more than the recommended dose of cannabis (Schedule I substance), and avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medication affects you. Talk to your doctor or pharmacist if you have any questions or concerns.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See Also

  • Cannabis Drug Interactions
  • Ibuprofen Drug Interactions
  • Ibuprofen General Consumer Information
  • Drug Interactions Checker
Drug Interaction Classification
These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.

Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some mixtures of medications can lead to serious and even fatal consequences.

View drug interactions between cannabis and ibuprofen. These medicines may also interact with certain foods or diseases.

Can CBD Substitute Ibuprofen In Pain And Inflammation Control?

Cannabis has been used for centuries to alleviate pain, and scientists are now aiming to discover a link between cannabinoids and their analgesic and anti-inflammatory potential. What does the research say about CBD as a future alternative to nonsteroidal anti-inflammatory drugs like ibuprofen?

Pain and inflammation are part of everyone’s life. These events are natural reactions of our body triggering a self-healing attempt, which is often successful. When pain increases, it’s likewise natural to seek help from outside the body. Nonsteroidal anti-inflammatory drugs, or NSAIDs, are the most common painkillers and anti-inflammatory drugs for conditions that are not too severe.

Ibuprofen is one of the most common anti-inflammatory drugs, discovered in 1961 and today available under several trade names. Other common NSAIDs include aspirin, diclofenac, ketoprofen, and a few more. They are effective in reducing or eliminating pain, inflammation, fever, headaches, rheumatoid arthritis and more, but these drugs have serious potential side effects, such as ulcers, heartburn, headaches, dizziness, liver or kidney diseases, high blood pressure, heart attack, and stroke.


When the body suffers an injury, compounds called prostanoids are produced. These include prostaglandins, which are involved in inflammation, and thromboxane, which is involved in blood clotting. These compounds are produced by cyclooxygenase enzymes called COX-1 and COX-2.

Like other anti-inflammatory and pain-control drugs, ibuprofen inhibits the release of these chemical compounds generated by our body’s response to an injury, trauma, or infection. Ibuprofen inhibits the production of prostaglandins by decreasing the activity of the enzyme cyclooxygenase, but, just like aspirin, ibuprofen is a non-selective COX inhibitor. This means it inhibits both COX-1 and COX-2 enzymes, potentially causing more side effects than other select NSAIDs. However, ibuprofen is effective against the symptoms of general pain, head pain, joint inflammation or damage, fever, rheumatoid arthritis, gout, minor musculoskeletal injuries, and rheumatic diseases. Still, a lot of people make large use of this drug without being fully aware of its side effects and risks for their health.


The endocannabinoid system is mainly active in pain control at the central nervous system level, but it’s also active in peripheral systems against painful and itchy symptoms of inflammation generated by dermatitis and allergies. Through their action on our endocannabinoid system, endogenous and exogenous cannabinoids are able to modulate pain thresholds and inhibit the release of proinflammatory molecules, just like ibuprofen. Moreover, they exert synergistic effects with other systems in our body that modulate pain, such as the endogenous opioid system.

Preclinical [1] and clinical studies have implicated the anti-inflammatory and pain-controlling potential of cannabinoids, suggesting the cannabis derivatives may prove useful for conditions related to acute or chronic pain—even conditions that are often refractory to conventional therapies. In particular, one study suggests [2] that CBD reduces the inflammatory response by lowering the production of proinflammatory cytokines by the immune system. A second research paper [3] claims that the compound may also inhibit some of the receptors responsible for pain perception.

Several clinical trials have proposed the safety and potential efficacy of THC and CBD for those with central and peripheral neuropathic pain [4] , rheumatoid arthritis, and cancer pain. In fact, the World Anti-Doping Agency (WADA) [5] recently removed CBD from its list of banned substances. This has allowed many professional athletes to join others in using CBD before and after competing or exercising.

Scientific investigation into cannabinoids for pain has influenced thousands of patients to reconsider what they take to manage pain and its associated symptoms. As opposed to many prescription drugs, THC’s side effects are generally well-tolerated, while the side effects of CBD are reported to be minimal by the World Health Organisation [6] . As part of their 2018 review into the compound, the WHO found that “CBD is generally well tolerated with a good safety profile. Reported adverse effects may be as a result of drug-drug interactions between CBD and patients’ existing medications”.

CBD Oil 15%
CBD Oil 15%
THC: 0.2%
CBD: 15%
CBD per drop: 7.5 mg
Olive Oil


Today, we can find plenty of CBD products on the market. Along with CBD oils, there are capsules, sublingual tinctures, edibles, topical creams, liquids for vaporization, and, of course, CBD-rich cannabis strains. Smoking, vaporizing, oral consumption, and sublingual administration offer vastly different levels of bioavailability, leading some individuals to combine different administration methods: a few oral applications a day, inhaling vapor as needed, and a topical cream on affected areas.

The WHO review also found that, “To date, there is no evidence of recreational use of CBD or any public health-related problems associated with the use of pure CBD”, going on to add, “In humans, CBD exhibits no effects indicative of any abuse or dependence potential”.

However, most users start out with low doses, slowly increasing intake over a period of days or weeks until they reach their required dosage. The main precaution when using CBD is to understand that it may affect the way other drugs are metabolised, potentially augmenting or decreasing their effectiveness. If you are currently on medication and wish to start using CBD, do consult your physician first.

Some cannabis users find that cannabis strains, or derivatives, rich in THC work best against painful symptoms, while others prefer products that contain little or no THC, or a balance of both CBD and THC. Cannabis terpenes also display attributes that may be complementary to pain treatment [7] , and this is the reason why a full spectrum extract is usually preferred to a single isolated cannabinoid, according to the “entourage effect” theory [8] .

There is still an incredible amount to learn regarding CBD’s interaction with other medications, our pain receptors, and what an ideal dose may look like. Thankfully, research is ongoing, with our understanding of the compound’s intricacies developing in kind. We may not be able to give a definitive answer on CBD as a future alternative to NSAIDs, but what we can say is, watch this space for future developments!

Research confirms cannabinoids as potent painkillers and anti-inflammatory compounds. Can CBD and THC provide the same relief as ibuprofen?