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The cannabinoid quinol VCE-004.8 alleviates bleomycin-induced scleroderma and exerts potent antifibrotic effects through peroxisome proliferator-activated receptor-γand CB2 pathways. The endocannabinoid system and its therapeutic exploitation. New drugs and new molecular entities in dermatology. Cannabinoid 1 receptors in keratinocytes attenuate fluorescein isothiocyanate-induced mouse atopic-like dermatitis. Hanuš LO, Meyer SM, Muñoz E, Taglialatela-Scafati O, Appendino G.

Nonpsychotropic plant cannabinoids, cannabidivarin (CBDV) and cannabidiol (CBD), activate and desensitize transient receptor potential vanilloid 1 (TRPV1) channels in vitro: potential for the treatment of neuronal hyperexcitability. Topical cannabinoid receptor 1 agonist attenuates the cutaneous inflammatory responses in oxazolone-induced atopic dermatitis model. The cannabinoid CB2 receptor inverse agonist JTE-907 suppresses spontaneous itch-associated responses of NC mice, a model of atopic dermatitis. Marquart S, Zerr P, Akhmetshina A, Palumbo K y cols. Inactivation of the cannabinoid receptor CB1 prevents leukocyte infiltration and experimental fibrosis. Taming THC: potential cannabis synergy and phytocannabinoid-terpenoid entourage effects. Role of Endocannabinoid Activation of Peripheral CB1 Receptors in the Regulation of Autoimmune Disease. The CB(2) receptor and its role as a regulator of inflammation. Cannabinoids inhibit human keratinocyte proliferation through a non-CB1/CB2 mechanism and have a potential therapeutic value in the treatment of psoriasis. Immunological and molecular targets of atopic dermatitis treatment.

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